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Stability studies of optimized (F6) orally dissolving strip formulation of clobazam stored at 40°C/75% RH.
| Parameters | Time points (days) | |||||
|---|---|---|---|---|---|---|
| 0 | 15 | 30 | 45 | 60 | 90 | |
| Disintegration time (sec) | 24 ± 0.5 | 22.5 ± 0.1 | 23 ± 0.2 | 22 ± 0.5 | 23 ± 0.4 | 23.2 ± 0.5 |
| Tensile strength (N/cm2) | 2.85 ± 0.03 | 2.80 ± 0.02 | 2.81 ± 0.03 | 2.85 ± 0.03 | 2.70 ± 0.05 | 2.80 ± 0.05 |
| In vitro drug release (%) | 96.6 ± 0.74 | 96.0 ± 0.12 | 96.0 ± 0.02 | 96.7 ± 0.02 | 96.8 ± 0.61 | 95.6 ± 0.70 |
