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. 2014 Oct 13;5:218. doi: 10.3389/fphar.2014.00218

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Copyright © 2014 Demin, Yakovleva, Kolobkov and Demin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of simulated average inhibition of glucose reabsorption mediated by SGLT2 and clinically measured glucose reabsorption inhibition levels during treatment with dapagliflozin. Comparison of the average inhibition of glucose reabsorption mediated by SGLT2 (simulated in the model) and levels of glucose reabsorption inhibition (measured in experiment) on the 14th day following multiple administrations of different doses of dapagliflozin (Komoroski et al., 2009a). Model simulations are presented with 95% confidence bands.