Table 5.
Bacteriological Success (Eradication/Presumed Eradication) Rates by Baseline Pathogen at TOC (10–45 D Post-Therapy) (MBV Population)
| Organism | Moxifloxacin n/N (%) | Comparator n/N (%) |
|---|---|---|
| Gram-positive aerobic | 155/197 (78.7) | 161/195 (82.6) |
| Enterococcus avium | 21/25 (84.0) | 18/23 (78.3) |
| Enterococcus faecalis | 28/36 (77.8) | 30/42 (71.4) |
| Enterococcus faecium | 17/23 (73.9) | 15/20 (75.0) |
| Streptococcus anginosus | 47/59 (79.7) | 56/65 (86.2) |
| Streptococcus constellatus | 42/54 (77.8) | 42/45 (93.3) |
| Gram-negative aerobic | 351/420 (83.6) | 335/387 (86.6) |
| Citrobacter freundii | 9/11 (81.8) | 12/13 (92.3) |
| Enterobacter cloacae | 10/13 (76.9) | 8/9 (88.9) |
| Escherichia coli | 227/269 (84.4) | 236/270 (87.4) |
| Klebsiella oxytoca | 21/24 (87.5) | 15/18 (83.3) |
| Klebsiella pneumoniae | 27/32 (84.4) | 25/31 (80.6) |
| Pseudomonas aeruginosa | 43/52 (82.7) | 30/36 (83.3) |
| Proteus mirabilis | 14/19 (73.7) | 9/10 (90.0) |
| Gram-positive anaerobic | 22/31 (71.0) | 33/39 (84.6) |
| Clostridium species | 18/23 (78.3) | 24/28 (85.7) |
| Peptostrepcococcus species | 4/8 (50.0) | 9/11 (81.8) |
| Gram-negative anaerobic | 237/279 (85.0) | 222/254 (87.4) |
| Bacteroides distasonis | 16/18 (88.9) | 14/16 (87.5) |
| Bacteroides fragilis | 90/107 (84.1) | 101/114 (88.6) |
| Bacteroides ovatus | 19/24 (79.2) | 14/15 (93.3) |
| Bacteroides thetaiotaomicron | 48/56 (85.7) | 49/56 (87.5) |
| Bacteroides uniformis | 16/17 (94.1) | 19/23 (82.6) |
| Bacteroides vulgatus | 17/20 (85.0) | 7/9 (77.8) |
| Other Bacteroides species | 31/37 (83.8) | 18/21 (85.7) |
MBV=microbiologically valid; TOC=test-of-cure.