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. 2014 Oct 13;5:167. doi: 10.3389/fendo.2014.00167

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Copyright © 2014 Roujeau, Jockers and Dam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential therapeutic targets for the prevention or reversal of leptin resistance. Potential therapeutic strategies to prevent or reverse leptin resistance: (1) increase of leptin signaling with new OBR agonists, (2) decrease of the inhibitory function of OBR negative regulators (SOCS3, PTP1B), (3) increase of leptin transport across the blood–brain barrier or median eminence, (4) increase of OBR cell surface expression by enhancing OBR anterograde traffic and recycling or by decreasing OBR constitutive internalization and lysosomal degradation (endospanin 1-dependent pathways), and (5) decrease of ER stress.