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. 2014 Sep 12;136(40):14068–14077. doi: 10.1021/ja505017f

Figure 2.

Figure 2

The transmembrane domain of ADCK3 has a conserved Gly-zipper motif. (a) Domain organization of ADCK3 homologues, which are proteins associated with the mitochondrial inner membrane. They are predicted to contain a TM domain (yellow) and a protein kinase-like domain (white). (b) The sequence alignment of the TM domains of ADCK3, ADCK4 (yellow box). The TM domains of ADCK3 and ADKC4, which differ only at two positions, contain a number of GxxxG-like motifs, including an extended Gly-zipper motif (red) and a second AxxxG motif which is off-register by two positions (magenta). (c) Sequence logo of the alignment of 400 sequences homologous to ADCK3 from a broad range of eukaryotic species highlights conservation in the TM domain and in the N-terminal side of the juxta-membrane region. All Gly positions in the Gly-zipper (red) appear strongly conserved. The most conserved positions in the TM region are L220 and G227. Identifiers of the sequences used for the alignment are provided in Supplementary Text S1 (SI).