Table 1. Characteristics of the eligible studies included in this meta-analysis.
| Diagnostic criteria(mmHg) | Mean blood pressure(mm Hg) | Mean age (years) | Gender (Female(%)) | BMI (kg/m2) | Cholesterol (mmol/L) | Triglycerides (mmol/L) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | ||||||||||||||||||||
| Studied SNP and First author | Year | Country | Ethnicity | Genotyping method | Source of controls | Hypertensive | Normotensive | Systolic BP | Diastolic BP | Systolic BP | Diastolic BP | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls |
| G1155942T (Ala 589 Ser;exon8) | |||||||||||||||||||||
| Lv JY | 2003 | China | Caucasian | RT-PCR | NA | ≥140/90 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erlich PM et al.(Population 2) | 2003 | America | Negroid | PCR/Homogeneous MassEXTEND | HB | ≥140/90a,b | <130/80c | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sun ZJ et al. | 2009 | China | Mongloid | PCR-RFLP | PB | ≥140/90a,b | <140/90 | 156.12 ± 25.56 | 96.88 ± 11.92 | 113.23 ± 12.73 | 73.78 ± 8.99 | 51.45 (12.09) | 49.50(13.97) | 141(54.4) | 136(57.9) | 25.37(6.54) | 22.02(3.57) | 5.09(1.02) | 4.39(1.08) | 1.68(1.36) | 1.06(0.86) |
| Lu M et al. | 2009 | China | Mongloid | TaqMan | PB | ≥140/90a,b | ≤ 120/80d | 159.7 ± 22.1 | 96.7 ± 13.2 | 112.2 ± 10.2 | 71.5 ± 6.8 | 49.0(7.5) | 48.7(10.8) | 334(73.7) | 291(64.0) | 28.3 (5.3) | 25.0(3.9) | 4.7(1.1) | 4.4(1.0) | 1.7(1.1) | 1.3(1.0) |
| Cao FF et al. | 2010 | China | Mongloid | TaqMan | PB | ≥140/90a,e | <140/90c | NA | NA | NA | NA | 48.86(10.47) | 46.17(10.18) | 309(54.9) | 207(59.8) | 26.36(4.20) | 24.49(3.74) | 5.17(1.52) | 4.72(1.59) | 1.39(0.94) | 1.17(0.86) |
| G1156666A (intron10) | |||||||||||||||||||||
| Erlich PM et al.(Population 1) | 2003 | America | Caucasian | PCR/Homogeneous MassEXTEND | HB | ≥140/90a,b | <130/80c | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erlich PM et al.(Population 2) | 2003 | America | Negroid | PCR/Homogeneous MassEXTEND | HB | ≥140/90a,b | <130/80c | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Speirs HJ et al. | 2004 | Australia | Caucasian | Homogeneous MassEXTEND | PB | ≥140/90 | <130/90 | 173 ± 25 | 106 ± 15 | 119 ± 10 | 72 ± 8 | 52(12) | 44(12) | 112(61) | 92(42) | 27(5) | 25(4) | 4.9(0.1) | 4.8(0.07) | 1.9(0.1) | 1.3(0.05) |
| Zhang LP et al. | 2008 | China | Mongloid | PCR-RFLP | PB | ≥140/90b | <140/90 | 160.2 ± 18.6 | 96.1 ± 15.2 | 113.9 ± 13.2 | 75.0 ± 11.2 | 62.8(4.3) | 61.8(6.6) | 106(55.5) | 101(58.4) | 26.5(5.6) | 24.4(4.1) | 5.1(1.5) | 4.8(1.9) | 1.3(0.8) | 1.1(0.6) |
| Lu M et al. | 2009 | China | Mongloid | TaqMan | PB | ≥140/90a,b | ≤120/80d | 159.7 ± 22.1 | 96.7 ± 13.2 | 112.2 ± 10.2 | 71.5 ± 6.8 | 49.0(7.5) | 48.7(10.8) | 334(73.7) | 291(64.0) | 28.3(5.3) | 25.0(3.9) | 4.7(1.1) | 4.4(1.0) | 1.7(1.1) | 1.3(1.0) |
| T1155547C (Ala 535 Ala; exon7) | |||||||||||||||||||||
| Erlich PM et al.(Population 2) | 2003 | America | Negroid | PCR/Homogeneous MassEXTEND | HB | ≥140/90a,b | <130/80c | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Lu M et al. | 2009 | China | Mongloid | TaqMan | PB | ≥140/90a,b | ≤120/80d | 159.7 ± 22.1 | 96.7 ± 13.2 | 112.2 ± 10.2 | 71.5 ± 6.8 | 49.0 (7.5) | 48.7(10.8) | 334(73.7) | 291(64.0) | 28.3(5.3) | 25.0(3.9) | 4.7(1.1) | 4.4(1.0) | 1.7(1.1) | 1.3(1.0) |
| Cao FF et al. | 2010 | China | Mongloid | TaqMan | PB | ≥140/90a,e | <140/90c | NA | NA | NA | NA | 48.86(10.43) | 46.31(10.14) | 307(55.2) | 206(60.4) | 26.36(4.20) | 24.47(3.78) | 5.18(1.52) | 4.72(1.60) | 1.38(0.94) | 1.17(0.86) |
| rs9916754 (C6749T; extron7) | |||||||||||||||||||||
| Wang F | 2008 | China | Mongloid | TaqMan | PB | ≥140/90a,b,e | <140/90c | 165.71 ± 22.50 | 103.57 ± 12.00 | 118.43 ± 12.27 | 77.22 ± 6.99 | 48.86(10.43) | 46.31(10.14) | 307(55.2) | 206(60.4) | 26.36(4.20) | 24.47(3.78) | 5.18(1.52) | 4.72(1.60) | 1.38(0.94) | 1.17(0.86) |
| Han Y et al.(The first study) | 2011 | China | Mongloid | PCR-RFLP | PB | ≥140/90a,b,e | <130/85 | 154.2 ± 20.0 | 93.9 ± 11.2 | 119.0 ± 10.8 | 76.5 ± 6.9 | 58.3(8.4) | 56.3(7.9) | 533(65) | 500(64.8) | 25.7(3.5) | 24.0(3.3) | 5.46(1.11) | 4.98(1.08) | NA | NA |
| Han Y et al.(The second study) | 2011 | China | Mongloid | PCR-RFLP | PB | ≥140/90a,b,e | <130/85 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
NA: not available; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; RT-PCR: real-time PCR; HB: hospital based; PB: population based; BMI: Body Mass Index; a: and/or under antihypertensive treatment currently; b: and excluded secondary hypertension; c: and not being treated with antihypertensive medications; d: and not been diagnosed as hypertensive previously; e: and/or diagnosed as hypertensive in the past.*The continuous variables are expressed as means ± SD.