Table 3. The main results of the meta-analysis of the association between the WNK4 variant.

		Sample size
Studied Polymorphisms	n	case	control	Genetic model	Statistical model	OR(95%CI)	Pz	I2 (%)	Pheterogeneity
C1155547T	3	1096	874	Allele contrast	Random model	1.54(0.90,2.63)	0.11	58.4	0.09
				Dominant	Random model	1.70(0.57,5.13)*	0.35	79.9	0.03
				Homozygous	Fixed model	2.49(0.57,10.78)*	0.22	0	0.86
G1156666A	5	1095	1029	Allele contrast	Random model	1.12(0.74,1.69)	0.6	54.8	0.07
				Dominant	Random model	1.08(0.68,1.71)	0.74	59	0.05
				Homozygous	Fixed model	3.40(0.86,13.54)#	0.08	0	0.8
G1155942T	5	2260	1567	Allele contrast	Random model		0.01	57.1	0.05
				Dominant	Random model		0.03	64.7	0.04
				Homozygous	Fixed model	1.67(0.80,3.49)	0.18	0	0.9
C6749T	3	1628	1411	Allele contrast	Fixed model		0	0	0.37
				Dominant	Fixed model		0	0	0.42
				Homozygous	Fixed model		0.02	0	0.59

*: for C1155547T, the study by Lu M et al. 2009 was excluded under the dominant and homozygous genetic model because of the absence of wild homozygote(CC) in both case and control group. #: for G1156666A, the study by Erlich PM et al. (population 2) 2003 was excluded under the homozygous genetic model because of the absence of mutational homozygote (AA) in both case and control group. : for G1155942T, the study by Lu M et al. 2009 was excluded under the dominant and homozygous genetic model because of the absence of wild homozygote(GG) in both case and control group. : OR had statistical significance with corresponding 95% CI greater than 1.