TABLE 1.
Interaction of KCNJ1 rs2855798, SLC12A1 rs1531916, and intakes of calcium with colorectal adenoma risk: the Tennessee Colorectal Polyp Study1
| Ge ne, SNP, and phase (all adenomas) | Cases/controls | MAF | P-interaction2 |
| n/n | |||
| KCNJ1, rs2855798 | |||
| I | 728/756 | 0.20/0.20 | 0.006 |
| II | 608/2135 | 0.20/0.20 | 0.03 |
| I and II | 1336/2891 | 0.20/0.20 | 0.0001 |
| KCNJ1, rs4529890 | |||
| I | 727/757 | 0.15/0.16 | 0.01 |
| II | 548/2063 | 0.14/0.14 | 0.06 |
| I and II | 1275/2820 | 0.15/0.15 | 0.001 |
| KCNJ1, rs4937378 | |||
| I | 728/757 | 0.23/0.23 | 0.01 |
| II | 547/2059 | 0.25/0.25 | 0.36 |
| I and II | 1275/2816 | 0.24/0.24 | 0.02 |
| KCNJ1, rs6590354 | |||
| I | 728/757 | 0.04/0.04 | 0.02 |
| II | — | — | — |
| SLC12A1, rs1531916 | |||
| I | 723/755 | 0.17/0.18 | 0.01 |
| II | 547/2061 | 0.22/0.21 | 0.72 |
| I and II | 1270/2816 | 0.19/0.19 | 0.08 |
1
KCNJ1, potassium inwardly-rectifying channel, subfamily J, member 1; MAF, minor allele frequency; SLC12A1, solute carrier family 12 member 1; SNP, single-nucleotide polymorphism.
2
Interactions between genetic polymorphism and calcium intake (continuous) by using a likelihood ratio test adjusting for age (continuous), sex, race (Caucasian, other), education (categorical), recruitment sites, BMI (categorical), smoking status (never, former, current), alcohol consumption status (never, former, current), physical activity (yes, no), and daily intakes of total energy and magnesium (continuous).