TABLE 1.
Characteristics of study participants by GSTM1 and GSTT1 genotype1
| GSTM1+ and GSTT1+ (n = 24) | GSTM1-null and GSTT1+ (n = 28) | GSTM1-null and GSTT1-null (n = 11) | P2 | |
| Age, y | 30.8 ± 6.7 | 30.3 ± 6.1 | 28.9 ± 4.5 | 0.69 |
| Height, cm | 169 ± 10.0 | 172 ± 9.3 | 167 ± 9.3 | 0.19 |
| Weight, kg | 71 ± 16.2 | 70 ± 13.5 | 70 ± 12.9 | 0.89 |
| BMI, kg/m2 | 24.7 ± 3.6 | 23.4 ± 2.8 | 24.7 ± 3.9 | 0.26 |
| Females, % | 50 | 43 | 64 | 0.03 |
| Race, % | 0.002 | |||
| Caucasian | 63 | 61 | 46 | |
| Asian | 25 | 32 | 36 | |
| Other3 | 13 | 7 | 18 | |
| Baseline serum inflammatory biomarker concentrations4 | ||||
| CRP, mg/L | 0.6 (0.4, 1.0) | 0.4 (0.3, 0.6) | 0.5 (0.2, 0.8) | 0.23 |
| IL-6, ng/L | 1.2 (1.0, 1.5) | 0.9 (0.8, 1.0) | 1.0 (0.6, 1.3) | 0.04 |
| IL-8,5 ng/L | 3.9 (2.7, 4.0) | 3.4 (2.9, 5.2) | 2.8 (2.2, 3.7) | 0.57 |
| TNF-α,5 ng/L | 3.0 (2.3, 4.2) | 4.8 (3.6, 6.2) | 1.6 (1.5, 4.7) | 0.06 |
| sTNFRI,5 μg/L | 0.95 (0.84, 1.08) | 0.97 (0.82, 1.14) | 0.92 (0.79, 1.06) | 0.94 |
| sTNFRII,5 μg/L | 3.89 (3.49, 4.33) | 4.30 (3.95, 4.69) | 4.23 (3.78, 4.74) | 0.43 |
1
Values are means ± SDs unless otherwise indicated; n = 63. CRP, C-reactive protein; GST, glutathione S-transferase; sTNFR, soluble TNF receptor.
2
Tests for significant differences across genotypes: chi-square for categorical variables, ANOVA for continuous variables.
3
Other category includes unknown/refused (n = 1), mixed race (n = 2), African American (n = 3), American Indian (n = 1), and Pacific Islander (n = 2).
4
Values are geometric means (95% CIs) based on a composite of 4 day 0 values.
5
n = 22, 24, and 8 for GSTM1+ and GSTT1+, GSTM1-null and GSTT1+, and GSTM1-null and GSTT1-null, respectively.