TABLE 2.
Effects of cruciferous and apiaceous vegetable diets on serum inflammatory biomarker concentrations in 63 healthy adults at the final day (day 14) of each diet period1
| Di et |
|||||
| Inflammatory marker | n | Basal | 1xC | 2xC | 1xC+A |
| CRP, mg/L | 63 | 0.43 (0.33, 0.54) | 0.53 (0.42, 0.68) | 0.41 (0.33, 0.53) | 0.35 (0.28, 0.45) |
| Change, % | — | 18.9 (−3.0, 63.0) | −4.9 (−25.0, 26.4) | −22.9 (−36.1, 7.5) | |
| IL-6, ng/L | 63 | 1.12 (0.98, 1.28) | 1.00 (0.87, 1.15) | 0.94 (0.82, 1.07)* | 0.93 (0.81, 1.07)* |
| Change, % | — | −12.0 (−25.3, 7.0) | −19.1 (−30.1, -0.1) | −20.4 (−31.0, −0.7) | |
| IL-8, ng/L | 56 | 2.94 (2.62, 3.29) | 3.21 (2.87, 3.59) | 3.28 (2.93, 3.66) | 3.49 (3.12, 3.90)* |
| Change, % | 8.4 (−4.2, 24.6) | 11.6 (−2.2, 27.0) | 15.8 (4.2, 35.2) | ||
| TNF-α, ng/L | 56 | 3.24 (2.89, 3.64) | 3.62 (3.20, 4.10) | 3.67 (3.28, 4.11) | 3.47 (3.08, 3.91) |
| Change, % | — | 10.4 (−5.1, 31.5) | 11.7 (−3.1, 32.0) | 6.6 (−8.8, 25.4) | |
| sTNFRI, μg/L | 56 | 0.93 (0.90, 0.96) | 0.96 (0.93, 0.99) | 0.92 (0.89, 0.95) | 0.94 (0.91, 0.97) |
| Change, % | — | 2.7 (−1.7, 7.4) | −1.8 (−6.1, 2.5) | 0.8 (−3.6, 5.3) | |
| sTNFRII, μg/L | 56 | 4.17 (4.02, 4.34) | 4.28 (4.12, 4.45) | 4.07 (3.92, 4.23) | 4.17 (4.00, 4.33) |
| Change, % | — | 2.6 (−3.0, 8.0) | −2.3 (−7.6, 2.9) | 0 (−5.6, 5.3) | |
1
Values are geometric means (95% CIs) adjusted for day 0 values, sex, age, body weight and GST genotype. The basal diet was devoid of fruits and vegetables. *Significantly different from basal, P < 0.05. CRP, C-reactive protein; GST, glutathione S-transferase; sTNFR, soluble TNF receptor; 1xC, single-dose cruciferous vegetable diet [7 g/(kg body weight · d)]; 1xC+A, single-dose cruciferous plus apiaceous vegetable diet [7 and 4 g/(kg body weight · d), respectively]; 2xC, double-dose cruciferous vegetable diet [14 g/(kg body weight · d)].