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. 2014 May 26;210(9):1419–1430. doi: 10.1093/infdis/jiu284

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© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 4. — Frequency of A(H1N1)pdm09-specific and A/Brisbane/59/2007-specific CD4⁺ T cells expressing at least 2 immune markers. Data shown are of the according-to-protocol cohort for immunogenicity at day 304. Group A received trivalent seasonal influenza vaccine (TIV) at day 0 and A(H1N1)pdm09 (3.75 µg)/AS03 at day 122 and day 143. Group B received TIV at day 0 and A(H1N1)pdm09 (15 µg) at day 122 and day 143. Group C received saline at day 0 and A(H1N1)pdm09 (3.75 µg)/AS03 at day 122 and day 143. Group D received saline at day 0 and A(H1N1)pdm09 (15 µg) at day 122 and day 143. Data are reported as the percentages of A(H1N1)pdm09-specific (A) or A/Brisbane/59/2007-specific (B) CD4⁺ T cells expressing (after in vitro stimulation) at least 2 immune markers among interferon-gamma, interleukin-2, tumor necrosis factor-alpha, and CD40L of all CD4⁺ T cells, with first and third quartiles, and the minimum/maximum values measured. Abbreviation: D, day.