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. 2012 Feb 16;4(1):51–59. doi: 10.1016/j.jare.2012.01.003

Table 3.

Determination of Ezetimibe and Atorvastatin calcium in Atoreza® tablets by the proposed methods and application of standard addition technique.

	D¹				IS								TLC-densitometry
					224.6 nm				238.6 nm
Product	Recovery^a % ±S.D.	Added μg mL⁻¹	Found^a μg mL⁻¹	Recovery %	Recovery^a % ±S.D.	Added μg mL⁻¹	Found^a μg mL⁻¹	Recovery %	Recovery^a % ±S.D.	Added μg mL⁻¹	Found^a μg mL⁻¹	Recovery %	Recovery^a % ±S.D.	Added μg band⁻¹	Found^a μg band⁻¹	Recovery %
Ezetimibe in Atoreza® tablets (Batch No. 1030599).	100.02 ± 1.29				101.05 ± 1.63				99.03 ± 0.91				100.44 ± 1.26
		5	5.06	101.2		8	8.05	100.63		8	8.15	101.88		0.1	0.102	102
		10	9.94	99.4		10	9.92	99.2		10	9.94	99.4		0.2	0.201	100.5
		15	15.23	101.53		12	12.23	101.92		12	11.84	98.67		0.4	0.407	101.75
Mean ± S.D.				100.71 ± 1.15				100.58 ± 1.36				99.98 ± 1.68				101.42 ± 0.80

	D¹				D²				TLC-densitometry
Product	Recovery^a % ±S.D.	Added μg mL⁻¹	Found^a μg mL⁻¹	Recovery %	Recovery^a % ±S.D.	Added μg mL⁻¹	Found^a μg mL⁻¹	Recovery %	Recovery^a % ±S.D.	Added μg band⁻¹	Found^a μg band⁻¹	Recovery %
Atorvastatin calcium in Atoreza® tablets (Batch No. 1030599).	99.48 ± 0.82	5.00	5.00	100.00	100.46 ± 0.83	8.00	7.88	98.50	100.14 ± 1.02	0.10	0.101	101.00
		10.00	10.17	101.70		10.00	10.09	100.90		0.20	0.203	101.50
		15.00	15.00	100.00		12.00	11.86	98.83		0.40	0.400	100.00
Mean ± S.D.				100.57 ± 0.98				99.41 ± 1.30				100.83 ± 0.76

^a

Average of three determinations