. 2012 Feb 16;4(1):51–59. doi: 10.1016/j.jare.2012.01.003

Table 4.

Statistical comparison of the results obtained by applying the proposed methods and the reported reference method for the analysis of Ezetimibe and Atorvastatin calcium in pharmaceutical dosage form.

	Ezetimibe				Atorvastatin calcium
		IS						Reported method^b
	D¹	224.6 nm	238.6 nm	TLC-densitometry	D¹	D²	TLC-densitometry	Ezetimibe	Atorvastatin calcium
Mean	100.02	101.05	99.03	100.44	99.48	100.46	100.14	100.27	100.01
S.D.	1.29	1.63	0.91	1.26	0.82	0.83	1.02	0.87	0.99
R.S.D. %	1.29	1.61	0.91	1.25	0.83	0.83	1.02	0.87	0.99
n	5	5	5	5	5	5	5	5	5
Variance	1.656	2.659	0.82	1.585	0.677	0.694	1.044	0.764	0.984
Student’s t-test (2.31)^a	0.366	0.981	2.209	0.252	0.923	0.786	0.204
F-value (6.39)^a	2.17	3.48	1.07	2.08	1.45	1.42	1.06

Figures between parentheses represent the corresponding tabulated values of t and F at P = 0.05.

Absorbance ratio method (Q-analysis) (Godse et al. [3]) at 238.6 nm (iso-absorptive point) and 232.6 nm (λ_max of Ezetimibe) [3].