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Biocompatibility study of the nanovesicles in vitro and in vivo. Cytotoxicity assay of bare vesicle (A) and its degradation products, PEG-polyserine (B), acetone (C), and ethanol (D) toward HeLa cells for 24 h. H&E stained sections of subcutaneously injected PBS (E) or VS(E+I) (F) with surrounding tissue after 4 weeks, respectively. Scale bar: 200 μm.
