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. Author manuscript; available in PMC: 2014 Oct 13.

Published in final edited form as: Toxicol Pathol. 2009 Dec 15;38(1):9–36. doi: 10.1177/0192623309354111

(A) Lung: hemangiosarcoma with hemorrhage and hemosiderin. (B) Lung, airway: organized fibrinous material and ingrowth of neoplastic endothelial cells. (C) Lung, vessel: neoplastic endothelial cells. (D) Lung: hemangiosarcoma. (E) Lung: small (possibly early) lesion with fibrinous material, fibrosis, and hypertrophic spindle (endothelial?) cells. (F) Lung: changes similar to those in 7E are present in this slightly larger lesion. (G) Lung: some lesions were predominately composed of fibrinous material and hemorrhage. (H) Lung: a larger lesion with fibrosis, hemorrhage, and hemosiderin. (I) Lung: higher magnification of (H). (J) Lung: the morphology of the bottom portion of this lesion looks similar to (I); however, there is unequivocal neoplastic transformation noted in the upper portion. (K) Lung: this lesion was diagnosed as angiomatous hyperplasia/fibrosis in the study, but there was no consensus from the audience.

(A) Lung: hemangiosarcoma with hemorrhage and hemosiderin. (B) Lung, airway: organized fibrinous material and ingrowth of neoplastic endothelial cells. (C) Lung, vessel: neoplastic endothelial cells. (D) Lung: hemangiosarcoma. (E) Lung: small (possibly early) lesion with fibrinous material, fibrosis, and hypertrophic spindle (endothelial?) cells. (F) Lung: changes similar to those in 7E are present in this slightly larger lesion. (G) Lung: some lesions were predominately composed of fibrinous material and hemorrhage. (H) Lung: a larger lesion with fibrosis, hemorrhage, and hemosiderin. (I) Lung: higher magnification of (H). (J) Lung: the morphology of the bottom portion of this lesion looks similar to (I); however, there is unequivocal neoplastic transformation noted in the upper portion. (K) Lung: this lesion was diagnosed as angiomatous hyperplasia/fibrosis in the study, but there was no consensus from the audience.