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Incidence of spontaneous neoplasia in Tg.AC mice (n = 110 animals per sex per group).
| Control |
TPA positive control |
|||
|---|---|---|---|---|
| Male | Female | Male | Female | |
| Skin | ||||
| Papilloma | 1 | 1 | 92 | 96 |
| Squamous cell carcinoma | 7 | 2 | ||
| Acanthosis/hyperplasia | 14 | 20 | 55 | 43 |
| Head | ||||
| Odontoma | 5 | 4 | 5 | 7 |
| Hematopoietic system | ||||
| Erythroleukemia | 7 | 5 | 7 | |
Abbreviation: TPA, 12-O-tetradecanoylphorbol-13-acetate.
