Table 5.

INHAND nomenclature criteria: Special techniques for oligodenroglioma diagnostics.

Positive immunostaining for MBP has been reported in human and rat oligodendrogliomas and may be of use to confirm a diagnosis in the mouse.

Also, CNP may be a useful diagnostic aid in cases of less differentiated tumors.

Some human oligodendroglioma express S-100 and Leu-7 marker, but expression cannot be regarded as specific for oligodendrogliomas.

In ENU-induced gliomas in rats most of the oligodendrogliomas react with Leu-7, were negative for GFAP, usually S-100 negative; Vimentin was also generally negative but might be focally positive.

Neoplastic oligodendrocytes may stain positively for galactose cerebroside and carbonic anhydrase C.

Abbreviations: CNP, 2′, 3′-cyclic nucleotide 3′-phosphodiesterase; ENU, ethylnitrosourea; INHAND, International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice; MBP, myelin basic protein.