Table 4. Partial correlation coefficients (R) between bone turnover markers/bone mineral density and fasting insulin/individual characteristics of metabolic syndrome defined by NCEP ATPIII.
Models a | OC | P1NP | ICTP | NTX | LS BMD | FN BMD | WB BMD | ||||||||
R* | P | R* | P | R* | P | R* | P | R* | P | R* | P | R* | P | ||
Insulin | Crude | −0.243 | 0.003 | −0.187 | 0.021 | 0.025 | 0.787 | −0.111 | 0.223 | −0.011 | 0.891 | 0.063 | 0.439 | −0.067 | 0.407 |
Model 1 | −0.239 | 0.003 | −0.195 | 0.016 | 0.071 | 0.459 | −0.130 | 0.156 | −0.018 | 0.825 | 0.022 | 0.784 | −0.123 | 0.127 | |
Model 2 | −0.168 | 0.043 | −0.108 | 0.190 | −0.034 | 0.718 | −0.053 | 0.572 | −0.097 | 0.236 | −0.058 | 0.477 | −0.084 | 0.305 | |
Model 3 | −0.162 | 0.053 | −0.093 | 0.266 | −0.040 | 0.675 | −0.056 | 0.556 | −0.065 | 0.433 | −0.089 | 0.289 | −0.075 | 0.364 | |
Glucose | Crude | −0.213 | 0.009 | −0.190 | 0.019 | −0.232 | 0.011 | −0.022 | 0.815 | 0.068 | 0.405 | 0.069 | 0.395 | 0.078 | 0.337 |
Model 1 | −0.211 | 0.010 | −0.228 | 0.005 | −0.124 | 0.182 | −0.079 | 0.394 | 0.053 | 0.517 | −0.063 | 0.118 | −0.075 | 0.351 | |
Model 2 | −0.152 | 0.066 | −0.179 | 0.029 | −0.189 | 0.044 | −0.025 | 0.789 | 0.033 | 0.689 | −0.097 | 0.235 | −0.018 | 0.828 | |
Model 3 | −0.099 | 0.240 | −0.133 | 0.110 | −0.169 | 0.076 | −0.017 | 0.861 | 0.032 | 0.696 | −0.114 | 0.176 | −0.017 | 0.839 | |
Triglycerides | Crude | −0.134 | 0.103 | −0.113 | 0.164 | −0.045 | 0.626 | −0.067 | 0.470 | −0.089 | 0.273 | 0.016 | 0.849 | −0.109 | 0.181 |
Model 1 | −0.126 | 0.126 | −0.136 | 0.097 | 0.054 | 0.565 | −0.112 | 0.224 | −0.108 | 0.189 | −0.083 | 0.312 | −0.228 | 0.005 | |
Model 2 | −0.037 | 0.656 | −0.048 | 0.562 | −0.038 | 0.690 | −0.041 | 0.660 | −0.185 | 0.024 | −0.165 | 0.044 | −0.210 | 0.010 | |
Model 3 | 0.005 | 0.949 | 0.000 | 0.998 | −0.014 | 0.886 | −0.029 | 0.762 | −0.181 | 0.028 | −0.158 | 0.060 | −0.204 | 0.014 | |
Waist circumference | Crude | −0.153 | 0.062 | −0.077 | 0.348 | −0.031 | 0.738 | −0.088 | 0.335 | 0.160 | 0.048 | 0.266 | 0.001 | 0.106 | 0.194 |
Model 1 | −0.148 | 0.073 | −0.112 | 0.172 | 0.136 | 0.142 | −0.169 | 0.065 | 0.156 | 0.054 | 0.114 | 0.076 | −0.060 | 0.457 | |
Model 2 | 0.042 | 0.617 | 0.106 | 0.199 | −0.013 | 0.888 | −0.069 | 0.461 | 0.158 | 0.054 | 0.104 | 0.207 | 0.064 | 0.436 | |
Model 3 | 0.069 | 0.414 | 0.138 | 0.097 | 0.006 | 0951 | −0.057 | 0.544 | 0.151 | 0.068 | 0.097 | 0.247 | 0.065 | 0.431 | |
HDL | Crude | 0.111 | 0.175 | 0.024 | 0.764 | 0.001 | 0.995 | 0.103 | 0.259 | −0.025 | 0.754 | 0.224 | 0.005 | −0.107 | 0.187 |
Model 1 | 0.100 | 0.227 | 0.045 | 0.584 | −0.131 | 0.160 | 0.164 | 0.073 | −0.008 | 0.927 | −0.121 | 0.136 | 0.100 | 0.221 | |
Model 2 | 0.056 | 0.504 | −0.012 | 0.888 | −0.086 | 0.365 | 0.131 | 0.159 | 0.031 | 0.708 | −0.086 | 0.296 | 0.002 | 0.979 | |
Model 3 | 0.059 | 0.485 | −0.044 | 0.596 | −0.109 | 0.255 | 0.107 | 0.256 | 0.012 | 0.889 | −0.081 | 0.332 | −0.015 | 0.855 | |
Systolic BP | Crude | −0.129 | 0.118 | −0.080 | 0.329 | −0.086 | 0.356 | 0.046 | 0.613 | 0.056 | 0.492 | 0.079 | 0.332 | 0.115 | 0.156 |
Model 1 | −0.119 | 0.150 | −0.113 | 0.165 | 0.069 | 0.463 | −0.012 | 0.899 | 0.038 | 0.642 | −0.075 | 0.361 | −0.043 | 0.600 | |
Model 2 | −0.057 | 0.495 | −0.056 | 0.499 | 0.016 | 0.866 | 0.044 | 0.635 | 0.012 | 0.885 | −0.115 | 0.162 | −0.004 | 0.959 | |
Model 3 | −0.027 | 0.750 | −0.030 | 0.720 | 0.027 | 0.778 | 0.047 | 0.623 | 0.016 | 0.845 | −0.119 | 0.154 | −0.003 | 0.972 | |
Diastolic BP | Crude | −0.109 | 0.185 | −0.042 | 0.606 | 0.002 | 0.983 | 0.124 | 0.174 | 0.009 | 0.914 | −0.047 | 0.565 | 0.018 | 0.823 |
Model 1 | −0.099 | 0.232 | −0.057 | 0.484 | 0.100 | 0.281 | 0.094 | 0.308 | −0.005 | 0.948 | −0.148 | 0.069 | −0.083 | 0.308 | |
Model 2 | −0.056 | 0.500 | −0.015 | 0.856 | 0.065 | 0.491 | 0.136 | 0.144 | −0.026 | 0.750 | −0.178 | 0.029 | −0.060 | 0.463 | |
Model 3 | −0.006 | 0.940 | 0.020 | 0.813 | 0.086 | 0.372 | 0.137 | 0.146 | −0.042 | 0.610 | −0.133 | 0.111 | −0.069 | 0.408 |
Abbreviations: OC, osteocalcin; P1NP, procollagen type 1 N-terminal propeptide; ICTP, carboxy-terminal telopeptide of type I collagen; NTX, N-terminal telopeptide urine collagen I aminoterminal telopeptide; BMD, bone mineral density; LS, lumbar spine; FN, femoral neck; WB whole body; HDL, high density lipoprotein cholesterol; BP, blood pressure.
Crude values and additional models: Model 1: + gender, Model 2: + fat mass and Model 3: + lifestyle factors (smoking, alcohol consumption and current physical activity).
*R, Correlation coefficients.