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. 2004 May 17;101(21):8096–8101. doi: 10.1073/pnas.0402594101

Fig. 3.

Fig. 3.

The galago minimal promoter silences expression of the γ-globin gene in adult erythropoiesis in transgenic mice. Effects of the galago γ-promoter or its promoter elements on humanγ-gene expression were assessed in the adult blood of transgenic mice carrying the corresponding construct. The line drawings at the top of each image show the constructs, and the differences between the test and control constructs are circled. Open and shaded bars with standard-deviation tabs show the expression levels of γ-gene expression in the controls and the experiments. The statistical significance (p) between experiment and control is indicated on the upper right corner of each histogram. (A) Comparison of effects of the human –159 minimal promoter and the galago –157 minimal promoter on expression of the γ-globin gene in adult erythropoiesis. (B) Comparison of the human CAC/CAT box with the galago CAC/CAT box. (C) Comparison of the human TATA box with the galago TATA box. (D) Comparison the human CAC box with the galago CAC box. (E) Comparison of the human CAT box with galago CAT box. (F) Comparison the human γCAC box with the human εCAC box.