Table 2. Expression of the human γ-gene in transgenic mice carrying a μLCRAγ construct with the human -159γ or the galago -157γ promoter.
| Human γ, % of murine α-mRNA per copy
|
|||||
|---|---|---|---|---|---|
| Embryonic erythropoiesis
|
Definitive erythropoiesis
|
||||
| Line | Copy no. | Day 12 blood | Day 12 yolk sac | Day 12 fetal liver | Adult blood |
| LCR(-157g)Aγ | |||||
| F | 7 | 16.0 ± 0.7 | 27.6 ± 2.5 | 7.8 ± 1.1 | 2.3 ± 0.6 |
| G | 15 | 1.4 ± 0.1 | |||
| H | 19 | 11.0 ± 0.6 | 25.0 ± 5.1 | 6.6 ± 0.4 | 1.3 ± 0.3 |
| I | 4 | 14.2 ± 6.1 | 19.5 ± 6.3 | 10.8 ± 4.2 | 1.6 ± 0.1 |
| J | 14 | 14.5 ± 2.2 | 30.8 ± 6.3 | 9.9 ± 0.5 | 1.3 ± 0.3 |
| K | 4 | 14.5 ± 0.2 | 23.9 ± 1.9 | 6.3 ± 0.1 | 0.7 ± 0.1 |
| Mean | 14.0 ± 1.8 | 25.4 ± 4.2 | 8.3 ± 2.0 | 1.4 ± 0.5 | |
| μLCR(-159h)Aγ | |||||
| L | 1 | 14.4 ± 0.7 | 36.9 ± 2.7 | 20.5 ± 0.2 | 13.4 ± 1.0 |
| M | 53 | 3.7 ± 0.1 | 16.5 ± 8.4 | 9.9 ± 1.1 | 17.7 ± 3.2 |
| N | 61 | 5.0 ± 0.9 | 23.1 ± 5.0 | 10.5 ± 0.9 | 10.1 ± 0.8 |
| O | 23 | 13.1 ± 2.2 | 30.0 ± 8.4 | 15.2 ± 3.4 | 16.1 ± 8.7 |
| Mean | 9.0 ± 5.5 | 26.6 ± 8.8 | 14.0 ± 4.9 | 14.3 ± 3.3 | |
See Table 1 legend and footnote.