Table 4. Human γ-globin gene expression in transgenic mice carrying the construct μLCR(-159h)Aγ(CACg) or μLCR(-159h)Aγ(CATg).
| Human γ, % of murine α-mRNA per copy
|
|||||
|---|---|---|---|---|---|
| Embryonic erythropoiesis
|
Definitive erythropoiesis
|
||||
| Line | Copy no. | Day 12 blood | Day 12 yolk sac | Day 12 fetal liver | Adult blood |
| μLCR(-159h)Aγ(CACg) | |||||
| AA | 23 | 17.9 ± 3.1 | 55.9 ± 5.0 | 7.4 ± 0.6 | 4.6 ± 0.4 |
| BB | 15 | 30.2 ± 2.9 | 41.4 ± 7.5 | 6.8 ± 0.9 | 4.6 ± 0.7 |
| CC | 4 | 24.1 ± 3.5 | 32.4 ± 3.8 | 8.2 ± 2.0 | 4.0 ± 0.3 |
| DD | 13 | 20.7 ± 0.7 | 33.9 ± 2.2 | 9.2 ± 0.4 | 4.3 ± 1.3 |
| Mean | 23.2 ± 5.3 | 40.9 ± 10.7 | 7.9 ± 1.0 | 4.4 ± 0.3 | |
| μLCR(-159h)Aγ(CATg) | |||||
| EE | 6 | 28.0 ± 7.0 | 30.4 ± 5.2 | 26.8 ± 0.1 | 11.3 ± 1.4 |
| DD | 18 | 23.4 ± 2.8 | 68.5 ± 21.0 | 17.9 ± 1.7 | 13.5 ± 0.5 |
| FF | 4 | 16.9 ± 1.7 | 29.8 ± 2.1 | 12.3 ± 2.6 | 6.7 ± 0.9 |
| Mean | 22.8 ± 5.6 | 42.9 ± 22.2 | 19.0 ± 7.3 | 10.5 ± 3.5 | |
| μLCR(-159h)Aγ | |||||
| Mean | 9.0 ± 5.5 | 26.6 ± 8.8 | 14.0 ± 4.9 | 14.3 ± 3.3 | |
See Table 1 legend and footnote.