Table 5. Human γ-globin gene expression in transgenic mice carrying the construct μLCR (-382h)Aγ (εCACh).
| Human γ, % of murine α mRNA per copy
|
|||||
|---|---|---|---|---|---|
| Embryonic erythropoiesis
|
Definitive erythropoiesis
|
||||
| Line | Copy no. | Day 12 blood | Day 12 yolk sac | Day 12 fetal liver | Adult blood |
| μLCR(-382h)Aγ(εCACh) | |||||
| GG | 1 | 15.5 ± 3.3 | 26.1 ± 0.9 | 16.5 ± 3.7 | 4.4 ± 0.9 |
| HH | 3 | 6.4 ± 1.2 | |||
| II | 1 | 19.7 ± 1.4 | 21.0 ± 3.2 | 13.9 ± 4.5 | 4.0 ± 0.8 |
| JJ | 4 | 16.7 ± 2.5 | 30.8 ± 6.2 | 10.7 ± 1.3 | 3.7 ± 0.7 |
| Mean | 17.3 ± 2.2 | 26.0 ± 4.9 | 13.7 ± 2.9 | 4.6 ± 1.2 | |
| μLCR(-382h)Aγ | |||||
| Mean | 10.4 ± 9.5 | 21.0 ± 7.4 | 11.8 ± 2.8 | 16.5 ± 4.5 | |
See Table 1 legend and footnote.