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. 2014 Oct 13;9(10):e109756. doi: 10.1371/journal.pone.0109756

Figure 2. Time-depended influence of bortezomib on TRAIL or DR5-B mediated cell death in HCT116 p53+/+ and HCT116 p53−/− cells.

Figure 2

(A) Viability of the cells treated with different concentrations of TRAIL or DR5-B during 8, 16, 20 and 24 h of incubation. (B) Viability of the cells treated with 1 nM bortezomib and different concentrations of TRAIL or DR5-B during 8, 16, 20 and 24 h of incubation. (C) Cells were incubated with different concentrations of bortezomib and cell death was measured after 24 h of incubation. (D) Calculation of effective concentrations of TRAIL variants after 24 h treatment of cells with 1 nM bortezomib. Values are mean ± SD of at least three independent experiments.