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. 2014 Oct 13;9(10):e109623. doi: 10.1371/journal.pone.0109623

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© 2014 Jayachandran et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Stem cells reside in the bone marrow, proliferate, mature and enter the circulation as fully functional leukocytes. Stem cells receive biochemical feedback for proliferation from the circulating blood. On treatment initiation, 6-MP enters the bone marrow and imparts cytotoxicity to the stem cells. Leukocytes and RBC MCV in the circulating blood are routinely measured and used as a dose-limiting parameter. A. Leukopoiesis, B. Erythropoiesis. Additional compartment for MCV was added to account for the dynamic changes following 6-MP treatment. Solid arrows represent cellular movement; dashed arrow represents property changes.