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. 2014 Oct 13;9(10):e109623. doi: 10.1371/journal.pone.0109623

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© 2014 Jayachandran et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Evolution of leukocyte count in response to optimum 6-MP dosing. Dashed line represents critical leukocyte level and solid dots represent clinical data for an average patient. B. Optimum 6-MP dosing profile predicted by NMPC. The standard daily 6-MP dosing is 75 mg/day.