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Effect of hypoxia on FUT7 (A), ST3O (B), UGT1 (C), and SDC4 (D) promoter activity. The reporter construct of each gene was transfected to SW480 cells and cultured for 12, 24, or 48 h under hypoxic (1% O2) or normoxic (20% O2) conditions. (Lower) Effect of cotransfection of the dominant-negative form of HIF (DN-HIF). The same amount of empty vector served as negative control, and nonmutated HIF-1 and HIF-2 constructs in the same vector served as positive controls.
