Table 1. SNPs associated with Childhood ALL at P<5×10−8.
| Alleles(A/B)b | ALL v Controls | B-ALL (n = 319) vs Controls (n = 1192) | |||||||||
| MAF | |||||||||||
| Typeda | rs ID | Chr | Position | Gene (location) | Cases (n = 358) | Controls (n = 1192) | Allelic OR(95% CI)c | P | Allelic OR(95% CI)c | P | |
| --- | rs4245595 | 10 | 63722895 | ARID5B (intronic) | T/C | 0.46 | 0.34 | 1.63 (1.38–1.93) | 2.13E-09 | 1.86 (1.54–2.25) | 1.21E-10 |
| --- | rs7090445 | 10 | 63721176 | ARID5B (intronic) | T/C | 0.46 | 0.34 | 1.63 (1.37–1.93) | 2.81E-09 | 1.83 (1.51–2.20) | 2.88E-10 |
| --- | rs4948492 | 10 | 63719739 | ARID5B (intronic) | T/C | 0.46 | 0.34 | 1.63 (1.37–1.93) | 2.84E-09 | 1.82 (1.51–2.20) | 2.91E-10 |
| --- | rs7896246 | 10 | 63724390 | ARID5B (intronic) | G/A | 0.46 | 0.34 | 1.61 (1.36–1.91) | 4.63E-09 | 1.81 (1.50–2.19) | 5.11E-10 |
| --- | rs4245597 | 10 | 63725942 | ARID5B (intronic) | A/G | 0.46 | 0.35 | 1.6 (1.35–1.9) | 5.87E-09 | 1.81 (1.50–2.19) | 5.99E-10 |
| --- | rs10821937 | 10 | 63723909 | ARID5B (intronic) | T/C | 0.46 | 0.35 | 1.6 (1.35–1.9) | 6.36E-09 | 1.81 (1.50–2.18) | 6.96E-10 |
| --- | rs10821936 | 10 | 63723577 | ARID5B (intronic) | T/C | 0.46 | 0.35 | 1.6 (1.35–1.9) | 6.36E-09 | 1.81 (1.50–2.18) | 6.95E-10 |
| --- | rs7087507 | 10 | 63745689 | ARID5B (intronic) | A/G | 0.46 | 0.35 | 1.62 (1.37–1.92) | 6.96E-09 | 1.80 (1.50–2.18) | 6.99E-10 |
| --- | rs1110701 | 7 | 50478627 | IKZF1 (3′ Flanking) | A/G | 0.39 | 0.28 | 1.69 (1.42–2.02) | 7.26E-09 | 1.91 (1.57–2.32) | 8.27E-11 |
| --- | rs9415635 | 10 | 63753482 | ARID5B (intronic) | A/G | 0.46 | 0.34 | 1.6 (1.35–1.89) | 2.17E-08 | 1.76 (1.46–2.12) | 2.96E-09 |
| rs7089424 | rs7089424 | 10 | 63752159 | ARID5B (intronic) | T/G | 0.46 | 0.34 | 1.6 (1.35–1.89) | 2.35E-08 | 1.76 (1.46–2.12) | 3.26E-09 |
| --- | rs10272724 | 7 | 50477213 | IKZF1 (3′ Flanking) | T/C | 0.37 | 0.26 | 1.67 (1.4–1.99) | 3.71E-08 | 1.90 (1.56–2.31) | 1.93E-10 |
| --- | rs17133807 | 7 | 50477687 | IKZF1 (3′ Flanking) | G/A | 0.37 | 0.26 | 1.66 (1.39–1.98) | 3.88E-08 | 1.90 (1.56–2.32) | 1.93E-10 |
a
Genotyped SNPs indicated in this column, dashed entries indicate imputed SNPs.
b
Allele B is the minor allele for all SNPs in this table.
c
Odds ratios represent the effect of additional copies of the B (minor allele).
Abbreviations: MAF, Minor Allele Frequency; Chr, Chromosome; OR, Odds Ratio; CI, Confidence Interval; P, P-value; B-ALL, B-cell Acute Lymphoblastic Leukemia.