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. 2014 Oct 13;9(10):e110185. doi: 10.1371/journal.pone.0110185

Figure 4. Effect of P2X7 receptor inhibitor Brilliant Blue G (BBG) on lung histology of wild-type (WT) mice after silica instillation.

Figure 4

Photomicrographs of lung parenchyma (hematoxylin-eosin) of wild-type animals 28 days after intratracheal instillation of saline (A, B) or silica particles (C, D), in the presence (B, D) or not (A, C) of BBG (45 mg/kg intraperitoneally two times per week for two weeks, 14 days after silica instillation). Bars: 1300 µm. E: nodular area quantification in lung parenchyma of silica instilled WT mice in the presence or not of BBG. Box plots represent median of 6 to 9 animals per experimental group with a statistical cut of ± 10-90%, with respective SD (15 random non-coincident fields/animal). *p <0.05.