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. 2014 Aug 7;33(18):1987–1998. doi: 10.15252/embj.201488883

Figure 2. FLC regulation.

Figure 2

FRI, PAF1, and COMPASS-like complexes are involved in activation/reset of FLC at every generation. During cold exposure, the PRC2-PHD complex and non-coding RNA COLDAIR are recruited at the nucleation region of FLC and catalyze H3K27 tri-methylation. After return to higher temperatures, PRC2-PHD associates across the entire region of FLC leading to cell-autonomous stable transcriptional silencing. After prolonged cold exposure, the number of cells in which FLC is stably silenced increases.