Table 4.

Up-regulated fibrosis-associated gene transcripts are shared between 9 and 14 d of synchronous regeneration and 10-d asynchronous remodeling

Genes	P-value/FC
	27–time point single regeneration series				Double injection LCM series
					4 d between injections		10 d between injections
	3/4 da	9/10 da	13/14 da	30/40 da	Single siteb	In-betweenb	Single siteb	In-betweenb
ACTA2 93100_at	0.001	0.006	0.002	NS	NS	0.005/8.3	NS	0.008/16.8
COL6A1 95493_at	0.003	0.0001	0.0001	0.02	NS	0.002/−3.6	NS	0.00004/7.2
COL18A1 101039_at	0.00001	0.0003	0.01	NS	NS	NS	NS	0.0001/4.0
COL4A2 101039_at	NS	0.01	0.008	NS	NS	NS	NS	0.0007/4.5
ELN 92207_at	NS	0.004	0.02	NS	NS	NS	NS	0.00004/3.2
MMP14 160118_at	0.0007	0.0002	0.006	NS	NS	NS	NS	0.0006/10.6
COL14A1 99476_at	0.007	0.004	0.002	NS	NS	NS	NS	0.0003/1.5
COL15A1 99637_at	0.02	NS	0.006	NS	NS	NS	NS	0.004/1.6
C2 103673_at	0.02	0.02	NS	NS	NS	NS	NS	0.000009/2.6
STAT3 99099_at	0.02	0.002	0.05	NS	NS	NS	NS	0.003/4.4
CDKNA1 94881_at	0.03	0.05	0.009	NS	NS	NS	NS	0.00007/3.25
RAMP2 994444_at	NS	0.007	0.006	NS	NS	NS	NS	0.0007/3.5
ACVR2B 994444_at	NS	0.007	0.006	NS	NS	NS	NS	0.0004/6.45

The 13 gene transcripts shown were significantly up-regulated in the region between asynchronous injection sites in the double LCM series when injections were separated by 10 d, but not 4 d (0/13). In the 27–time point synchronous regeneration time series, these same transcripts showed the highest and consistent up-regulated between 9 and14 d. FC, fold change.

^aDays are versus 0.

^bSites are versus nonregenerating.