Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Oct 13;207(1):41–57. doi: 10.1083/jcb.201406037

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Schwarz and Blower

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 7. — Model of XendoU nuclease activity on membranes. (A) The ER network exists as a mixture of tubules and sheets. A decrease in XendoU results in the expansion of sheets. (B) Ribosomes, ribonucleoproteins (RNPs), XendoU, Atlastin, and (closed) calcium channels are localized to membrane vesicles containing Ca²⁺. Dimerization of Atlastin leads to eventual membrane fusion and calcium release through calcium channels on the membrane. XendoU binds calcium and mediates local RNA degradation (mRNAs, rRNAs, other RNAs), resulting in the release of ribosomes, RNPs, and RNA from the surface of membranes.