Table 4.
Multivariable Analysis of Overall Survival in Oropharyngeal Cancer Patients With Disease Progression
| Covariate | Limited to Patients With Known Pack-Years (n = 154; 100 events) |
All Patients, With Imputed Pack-Years (n = 181; 123 events) |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| p16 status (positive v negative) | 0.48 | 0.31 to 0.74 | < .001 | 0.57 | 0.39 to 0.84 | .005 |
| T stage at enrollment (T4 v T2-T3) | 1.61 | 1.06 to 2.45 | .03 | 1.91 | 1.31 to 2.78 | < .001 |
| Progression type (distant v locoregional) | 1.99 | 1.28 to 3.09 | .002 | 1.70 | 1.13 to 2.54 | .01 |
| Salvage surgery (yes v no) | 0.48 | 0.27 to 0.84 | .01 | 0.56 | 0.34 to 0.92 | .02 |
| Pack-years (> 20 v ≤ 20) | 1.57 | 1.02 to 2.44 | .04 | 1.54 | 1.00 to 2.39 | .05 |
Abbreviation: HR, hazard ratio from Cox proportional hazards model stratified by protocol.