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. 2014 Oct 1;13:153. doi: 10.1186/1476-511X-13-153

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© Sachs-Barrable et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of pre-incubation with DAPP on P-gp transport of Rhodamine 123 across Caco-2 cell monolayer (basolateral to apical transport) and apparent Permeability Papp. Data represent the average of N = 6 ± SD. *p < 0.025. TEER values were measured before and after the treatment and at the end of the experiment. No changes in TEER values were seen which indicates the integrity of the monolayers. Treatment with DAPP lead to a statistically significant decrease in secretory flux compared with untreated control cells. Treatment with Verapamil represents a positive control for P-gp inhibition.