Table 2.
Biochemical parameters
| Clozapine (n=100) | Non-clozapine (n=21) | Controls (n=20) | p Value (ANCOVA) | |
|---|---|---|---|---|
| Biochemical parameters | ||||
| Haemoglobin (g/L) | 142±15 | 146±13 | 148±10 | 0.18 |
| White cell count (×109/L) | 8.2±2.6 | 7.4±2.4 | 6.5±1.5 | 0.17 |
| Neutrophil count (×109/L) | 5.4±2.2 | 4.3±1.8 | 3.6±1.0 | 0.02*† |
| Neutrophil count <2.0×109/L | 2 (2) | 3 (14) | 0 | 0.02 |
| Neutrophil count >7.0×109/L | 20 (20) | 2 (10) | 0 | 0.03 |
| Neutrophil : lymphocyte ratio | 2.9±1.7 | 1.9±1.0 | 1.7±0.8 | 0.01* |
| Eosinophil count (×109/L) | 0.12±0.1 | 0.23±0.1 | 0.17±0.1 | 0.006† |
| Fasting lipids (mmol/L) | ||||
| Total cholesterol | 5.2±1.1 | 5.3±1.0 | 4.9±0.7 | 0.24 |
| Total cholesterol >5.2 mmol/L | 40 (40) | 11 (52) | 4 (20) | 0.12 |
| Statin therapy | 18 (18) | 4 (19) | 0 | 0.96 |
| Triglycerides | 2.1±1.3 | 1.7±0.7 | 1.2±0.6 | 0.007* |
| Total triglyceride >2.0 mmol/L | 25 (25) | 3 (15) | 1 (5) | 0.41 |
| HDL-C | 1.2±0.3 | 1.1±0.4 | 1.4±0.3 | 0.05 |
| LDL-C | 3.0±0.9 | 3.3±0.8 | 3.0±0.7 | 0.06 |
| HsCRP (mg/L) | 4.3±4.3 | 3.4±5.4 | 0.9±0.8 | 0.05 |
| NT-proBNP (pmol/L) | 3.4±4.2 | 6.4±9.5 | 2.8±2.2 | 0.05 |
| HsTropT (ng/L) | 9.1±3.2 | 6.9±4.4 | 5.0±0.0 | 0.002‡† |
| Creatine kinase (U/L) | 145±129 | 167±253 | 129±52 | 0.36 |
| Creatine kinase >250 U/L | 14 (14) | 4 (19) | 2 (10) | 0.91 |
| HbA1c (%) | 5.9±1.0 | 6.0±1.0 | 5.6±0.9 | 0.39 |
Values are presented as mean±SD or absolute number (%).
ANCOVA with the following covariates in the modelling: age, alcohol excess, BMI, diabetes, gender, history of CCF, history of ischaemic heart disease, hypercholesterolaemia and smoking.
*Post hoc Tukey analysis with Bonferroni correction between clozapine and healthy controls, p value <0.05.
†Post hoc Tukey analysis with Bonferroni correction between patients receiving clozapine and non-clozapine patients, p value <0.05.
‡Post hoc Tukey analysis with Bonferroni correction between non-clozapine and healthy controls, p value <0.05.
ANCOVA, analysis of covariance; BMI, body mass index; CCF, congestive cardiac failure; HbA1c, glycosylated haemoglobin; HDL-C, high-density lipoprotein cholesterol; HsCRP, high-sensitivity C reactive protein; HsTropT, high-sensitivity Troponin T; LDL-C, low-density lipoprotein cholesterol; NT-proBNP, N-terminal pro-B-type natriuretic peptide.