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. 2014 Sep 23;12:74. doi: 10.1186/s12915-014-0074-4

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© Campbell et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Genome-wide map of HERV-mediated genome instability. Chromosome ideograms with 70 predicted HERV susceptibility regions indicated in purple flanked by individual HERV elements indicated in red. Potentially HERV-mediated CNVs identified in the Baylor College of Medicine or Signature Genomics clinical databases are shown below the chromosome ideograms in cyan. HERV-mediated CNVs that have been molecularly confirmed in this study or the literature are indicated in yellow. CNV, copy-number variation; HERV, human endogenous retrovirus.