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. 2014 Oct 2;10:64. doi: 10.1186/1744-8069-10-64

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© Mohammadi and Christie; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Chronic hot/cold hypersensitivity is normal in α9-nAChR KO mice. Thermal hyperalgesia was tested on a 54°C hotplate. Thermal hyperalgesia develops normally in both WT and α9-nAChR KO mice in an inflammatory pain model (A) and is characteristically absent in a neuropathic pain model (B). Cold allodynia is present in both genotypes after CCI and is maintained for at least 3 weeks post-injury (C).