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. 2014 Sep 25;14:356. doi: 10.1186/1472-6882-14-356

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© Sun et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of RM on lung infection induced by the P. aeruginosa PAK strain. (A) The survival rate of mice treated with RM or Cef upon challenge with P. aeruginosa. The survival rate was assessed for 24 h; (B) lung tissue pathology slices (the light microscopic images were captured at 100× magnification); (Control) control group, (Model) model group, (Cef) positive control group, (RM-H) high dose RM group, (RM-M) middle dose RM group,(RM-L) low dose RM group. Comparing with the control group, obvious inflammatory cell infiltration in mucosa and submucosa in model group; (C) effects of RM on the production of TNF-α, IL-6, IL-8 in mouse serum.Value were expressed as the mean ± SEM (n = 6). *p < 0.05, **p < 0.01,***p<0.001, compared to the model group (,). ^### p<0.001 compared to the control group.