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. 2014 Mar 11;19(9):1044–1051. doi: 10.1038/mp.2014.9

Figure 3.

Figure 3

(a) Percentage of Aβ+ and Aβ− MCI subjects progressing to dementia or reverting to cognitive normal (CN) status over 36 months. The bars depict the 36-month endpoint diagnostic status of subjects originally classified as MCI at baseline. The red and blue bars titled CN depict the percentage of MCI subjects who reverted to CN by amyloid status. The red and blue bars titled MCI depict the percentage of MCI subjects who continued to be classified as MCI at endpoint (that is, cognitive change was not sufficient to trigger conversion). The red and blue bars titled AD depict the percentage of MCI subjects who progressed to dementia by amyloid status. Conversion to dementia from MCI was almost three times higher in Aβ+ subjects while reversion to CN was almost three times lower than Aβ− subjects. The arrows depict conversion and reversion. Please see text for details. (b) Concomitant and initiation of AD medication use in MCI subjects over 36 months by baseline florbetapir PET status. The proportion of MCI subjects who started the study taking AD medications was greater among Aβ+ vs Aβ− subjects (35.3% vs 3.3% P=0.006). By study end, 70.6% of Aβ+ MCI subjects were taking AD medications vs 23.3% Aβ− MCI (P=0.002) because of the greater percentage who initiated AD medications in Aβ+MCI vs Aβ−MCI (54.5% vs 20.7%). Please see text for details.