Table 2.
Change in lung function with exercise with interaction term analyses (Subjects ≥ 10 years old)
| Models: n = 389 subjects | Estimated FEV1% at time = 0 without exercise* | Estimated FEV1% at time = 0 with exercise* (pvalue) | Baseline Change in FEV1% per year (pvalue) | Change in FEV1% over baseline per year with exercise (pvalue) | Change in FEV1% over baseline per year for interaction (pvalue) | |
|---|---|---|---|---|---|---|
| Any Exercise | Unadjusted Model (No Covariates) | 74.8 | 82.6 (0.020) | -2.01 (0.001) | 0.28 (0.67) | - |
| Adjusted Model | 81.7 | 81.6 (0.95) | -2.03 (0.001) | 0.35 (0.59) | - | |
| Adjusted Model + Interaction for Sex | 81.9 | 81.8 (0.92) | -2.03 (0.001) | 0.05 (0.94) | 0.67 (0.17) | |
| Adjusted Model + Interaction for Age | 82.2 | 82.1 (0.93) | -2.03 (0.001) | -0.45 (0.50) | 1.98 (<0.001) | |
| Adjusted Model + Interaction for Baseline FEV 1 | 81.6 | 81.4 (0.87) | -2.03 (0.001) | -0.10 (0.88) | 1.08 (0.028) | |
| Competitive Exercise | Unadjusted Model (No Covariates) | 77.9 | 85.7 (0.001) | -1.70 (<0.001) | -0.16 (0.74) | - |
| Adjusted Model | 81.7 | 81.6 (0.98) | -1.64 (<0.001) | -0.18 (0.70) | - | |
| Adjusted Model + Interaction for Sex | 81.7 | 81.7 (0.98) | -1.64 (<0.001) | -0.28 (0.61) | 0.22 (0.73) | |
| Adjusted Model + Interaction for Age | 81.1 | 81.1 (0.93) | -1.64 (<0.001) | -0.84 (0.11) | 1.83 (0.004) | |
| Adjusted Model + Interaction for Baseline FEV 1 | 81.7 | 81.6 (0.93) | -1.65 (<0.001) | -0.49 (0.35) | 0.87 (0.17) | |
*Estimated intercepts were calculated using the regression coefficients assuming the subject was male and had the mean values for baseline FEV1 percent predicted (80.8 ± 22.2), age of diagnosis (3.6 ± 7.5 years), and age at time of exercise ascertainment (19.5 ± 9.4 years)(n = 389). The estimated FEV1 values are not statistically different for the adjusted models owing to the adjustment for baseline FEV1.