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. 1995 May 9;92(10):4442–4446. doi: 10.1073/pnas.92.10.4442

ETS1 suppresses tumorigenicity of human colon cancer cells.

H Suzuki 1, V Romano-Spica 1, T S Papas 1, N K Bhat 1
PMCID: PMC41960  PMID: 7753825

Abstract

We have ectopically expressed transcription factor ETS1 in two different highly tumorigenic human colon cancer cell lines, DLD-1 and HCT116, that do not express endogenous ETS1 protein and have obtained several independent clones. The expression of wild-type ETS1 protein in these colon cancer cells reverses the transformed phenotype and tumorigenicity in a dose-dependent manner. By contrast, expression in DLD-1 cells of a variant form of ETS1, lacking transcriptional activity, did not alter the tumorigenic properties of the cells, suggesting that the reduction in tumorigenicity in these clones was specific for the wild-type ETS1 gene products. Since these colon cancer cells have multiple genetic alterations, the system described in this paper could be a good model to study the suppression of tumorigenicity at a transcriptional level, which could lead to the design and development of novel drugs for cancer treatment.

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Selected References

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