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. 2014 Oct 14;2:36. doi: 10.1186/s40425-014-0036-y

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© Pollack et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Functional avidity of NY-ESO-1 specific T cells. A. NY-ESO-1 specific T cell products from patients #1-#6. The left panel for each patient shows the lysis of T2 cells pulsed with various concentrations of NY-ESO-1 peptide by NY-ESO-1-specific T cells at an effector to target (E:T) ratio of 20:1. The right panel shows lysis of the NY-ESO-1 expressing tumor cell line MelA375 at various E:T ratios. The tumor cell line Mel526 (NY-ESO-1 negative, gp100 positive) is a negative control. B. Lysis of NY-ESO-1 peptide pulsed T2 cells and tumor cells by a high affinity NY-ESO-1 T cell clone isolated by our lab, T cells transfected with the αLY TCR and sorted to >80% purity with NY-ESO-1 tetramer, and a gp100_154-162 specific T cell clone.