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. 2014 Oct 5;12:281. doi: 10.1186/s12967-014-0281-3

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© Kang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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AKT2 re-expression rescues the inhibitory effect of let-7b/g. (A) AKT2 re-expression partly abolished the growth-inhibitory effect of let-7b/g in a 5-day MTT assays (*, P < 0.05; **, P < 0.001). The SDs were achieved by the 575 nm absorbance readings in 6 wells of each item. (B) AKT2 abrogated the suppressed monolayer colony formation by let-b/g (*, P < 0.05; **, P < 0.001). The experiments was performed in triplicate wells to get SDs. (C) AKT2 re-expression promoted in vivo tumor growth (**, P < 0.001).