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. 2014 Nov 1;37(11):1825–1832. doi: 10.5665/sleep.4180

Figure 1.

Figure 1

Serum VEGF and high sensitivity-CRP are elevated in OSA and MS patients. (A) Serum VEGF is elevated in 31 OSA patients and 13 MS patients compared to 16 non-OSA healthy controls, but not in 21 MS+OSA patients. * P < 0.05 vs controls, # P < 0.05 vs MS group, Two-way ANOVA. (B) Positive Spearman correlation between serum VEGF and time spent under 90% O2 saturation during sleep in OSA patients (P = 0.046) but not in healthy controls. (C) Positive Spearman correlation between serum VEGF and hsCRP in OSA patients and healthy controls (n = 47 subjects, P = 0.023). (D) Serum hsCRP is elevated in 31 OSA patients and 13 control MS patients compared to 16 non-OSA healthy controls, but not in 21 MS+OSA patients. * P < 0.05, Two-way ANOVA. (E) Positive Spearman correlation between hsCRP and severity of OSA measured by apnea-hypopnea index (AHI), n = 47 subjects, P = 0.015. (F) Negative Spearman correlation between hsCRP and minimal O2 saturation during sleep, both in healthy controls and OSA patients, n = 47 subjects, P = 0.003. In graphs B, C, E, and F, gray circles represent healthy controls (n = 16) and closed circles represent OSA patients (n = 31), both without MS.