Table 3.
Predicted targets of miRNAs downregulated by arctiin in H 2 O 2 -treated HHDPCs
| miRNA | Target genes and functions | |||
|---|---|---|---|---|
| Aging | Skin development | Apoptosis | Cell proliferation | |
| hsa-miR-1290 | HMGA2, NUAK1, TERF2, SLC1A2, FADS1, DDC | APC, COL8A1 | HMGA2, APC, RRN3, ITGAV, CSE1L, NOTCH1, GAS, BMI1, FOXC1, ROBO1, USP28 | HMGA2, BMI1, NUAK1, APC, MLL2, RRN3, ITGAV, CSE1L, NOTCH1, GAS, FOXC1, ROBO1, USP28, CDC27, HES1, COL8A1, NPR3, CDKN2B, FIGF, NRAS |
| hsa-miR-1915-3p | BCL2, SRF, SREBF2, HSD17B10 | SRF, DDR1, EDA | BCL2, MAPK311, ARHGEF2, CDK5R1, WNT3A, MMP9, THRA, MEF2D, SET, CD44 | DDR1, CDK2, DEAF1, TIRAP, BCL2, MAP3K11, ARHGEF2, CDK5R1, WNT3A, TNFSF11, WDR6, AZGP1, TAL1, DPT |
| hsa-miR-2861 | P2PY2, FADS1 | NGFR, EDA | NGFR, PTPRC, ITGA1, MAEL, FGD2, AKT2, PAX8 | NGFR, PTPRC, SLAMF1, HOXB4, AKT2, HOXB4, |
| hsa-miR-3665 | AQP2 | - | AQP2, FGFR1, BOK, TRIO, NOTCH1, PGAP2, PDPK1, BARD1 | BOK, FEZF1, ABCB1, FOXO4, EIF5A2, WNT9A, NDFIP1, FGFR1, NOTCH1, CDK13 |
| hsa-miR-4257 | TWIST1, CTSC, HMGA1 | COL2A1 | TWIST1, CTSC, IGF1R, IL10, GSK3B, RASSF5, COL2A1, AKT1S1, CD44, ASAH2 | TWIST1, HMGA1, IL10, INSR, MAPRE2, PA2G4, PRDM1, IGF1R, MMP14, EMX2, TRIM27, MCM7 |
| hsa-miR-452-5p | TIMP3 | - | SPRY2, PAX3, SOX7, LRP6, SNAI2, CSNK2A2, FGD4, PKN2, ITGA6, PDCD6IP | SPRY2, PAX3, SOX7, LRP6, SNAI2, RPA1, EPS8, NFIB, MAPRE1, ODZ1, CDCA7L, CD47, E2F3, PURA, RUNX1 |
| hsa-miR-513a-5p | SERP1, NEK6, CDK6, DLD, PRKCD, MAP2K1, MORC3, LRRK2, SLC1A2 | WNT7A, SFN, TFAP2B, APC | SPRY2, MLL, GATA3, BCL6, PRKCD, NEK6, MED1, PLK2, WNT7A, SFN, APC, HOXA5, AKAP13, USP47, MAP2K4, ISL1, MITF, STAT1, XIAP, TFAP2B, HDAC2, TRIM2, CREB1, MAP3K7, WNK3, SOS1, FGD4 | TFAP2B, WNT7A, APC, HGF, EBXW7, TSC1, KRAS, RXRB, XIAP, SPRY2, GATA3, BCL6, HOXA5, ISL1, MITF, STAT1, NFIB, E2F7, MAGI2, PDKK, HDAC2, MED1, EHF, LIFR, PURA, GATA2, ATF3, VIP, SOX11, RUNX1, RNF139, PCM1, TSHR, EPS8 |
| hsa-miR-572 | - | - | - | - |
| hsa-miR-629-3p | SOD2, VDR, EDN1, CHEK1, SLC34A2 | - | THOC1, MYO18A, TP53BP2, SOD2, VDR, EDN1, APC, PPARG, PIM1, ERBB4, PSMD2, PERP, BCL2L15 | DLG3, RTKN2, CDK9, STAT3, SOD2, VDR, EDN1, PPARG, PIM1, ERBB4, APC, STAT6, PDGFC, ZEB1, ID4, LIFR, NOLC1, EPHB1, ACSL6, EREG, CDK13, CDC27 |
| hsa-miR-765 | VDR, RELA, SOCS3, TIMP3, LOXL2 | PDGFA, ERRFI1 | DLG5, RARG, MED1, EGLN2, VDR, RELA, SOCS3, ERBB4, RNF41, ATG7, ARHGEF11, PDE5A, CXCL12, GLI3, DIDO1, CASP9, ACIN1 | CXCL12, GLI3, DLG5, RARG, VDR, RELA, ERBB4, PDE5A, MED1, PDGFA, CD34, GPC3, PDX1, COL8A1, PES1, TSC2, SF1, FTO, GABBR1, |
| hsa-miR-875-5p | TGFB3, SMC5 | TCF7L2 | TGFB3, TCF7L2, EYA1, MDM4, MEF2C, EGFR, WNK3 | MDM4, MEF2C, EGFR, FRS2, TGFB3, EYA1, TOB2, TBX18, CEP120, TCF7L2, TIRAP, RNF139, SALL1 |
| hsa-miR-940 | - | - | - | - |