Table 1. Binding kinetics parameters of different cell lines and clones.
Cell/Clone | kon 1 × 105 M−1s−1 | koff 1 × 10−4 s−1 | KD nM |
---|---|---|---|
SK-BR3 | 1.3 ± 0.4 | 3.4 ± 2.6 | 2.7 ± 2.0 |
BT474 | 6.2 ± 2.2 | 4.0 ± 2.4 | 0.7 ± 0.4 |
MCF7-Her2 | 3.6 ± 1.0 | 9.1 ± 4.3 | 2.5 ± 1.6 |
SK-BR3 (H6)[a] | 2.1 ± 1.0 | 5.4 ± 2.2 | 3.1 ± 2.5 |
SK-BR3 (C5)[a] | 1.3 ± 0.3 | 5.9 ± 2.6 | 5.5 ± 3.5 |
SK-BR3 (E8) | 7.4 ± 2.1 | 3.6 ± 1.5 | 0.5 ± 0.2 |
SK-BR3 (C11) | 3.5 ± 1.7 | 2.4 ± 0.9 | 0.7 ± 0.3 |
[a]Only the effective Her2 population was listed here.