Table 1.
Dose distribution parameters averaged over 20 patients
| Mean (SD) (n = 20) | p value | |||||
|---|---|---|---|---|---|---|
| BH | FB | BH compared to FB, for both IMPT and IMRT | IMPT compared to IMRT, for both BH and FB | |||
| IMPT | IMRT | IMPT | IMRT | |||
| Heart | ||||||
| Mean (Gy) | 0.1 (0) | 1.5 (0.5) | 0.2 (0.1) | 2.7 (1.3) | p < 0.01 | p < 0.01 |
| D max (Gy) | 0.3 (0.3) | 8.6 (6.2) | 1.2 (1.7) | 24.7 (14.7) | p < 0.01 | p < 0.01 |
| V5 Gy (%) | 0.1 (0.2) | 2.5 (2.1) | 0.5 (0.8) | 7.4 (4.7) | p < 0.01 | p < 0.01 |
| V20 Gy (%) | 0 | 0.6 (0.8) | 0.1 (0.2) | 3.5 (3.0) | IMPT: p = 0.02/IMRT: p < 0.01 | p < 0.01 |
| V30 Gy (%) | 0 | 0.3 (0.4) | 0 | 2.4 (2.3) | IMPT: p = 1.80/IMRT: p < 0.01 | p < 0.01 |
| LAD-region | ||||||
| Mean (Gy) | 0.3 (0.2) | 6.7 (5.1) | 0.7 (0.8) | 14.9 (9.3) | p < 0.01 | p < 0.01 |
| D max (Gy) | 1.8 (1.9) | 18.8 (13.6) | 4.5 (3.4) | 31.4 (13.0) | p < 0.01 | p < 0.01 |
| V5 Gy (%) | 0.4 (0.9) | 30.3 (25.9) | 2.8 (5.8) | 54.9 (25.1) | p < 0.01 | p < 0.01 |
| V10 Gy (%) | 0.1 (0.3) | 18.2 (21.5) | 0.8 (2.7) | 42.9 (26.6) | IMPT: p = 0.04/IMRT: p < 0.01 | p < 0.01 |
| V20 Gy (%) | 0 | 9.7 (15.1) | 0.1 (0.6) | 32.8 (27.1) | IMPT: p = 0.06/IMRT: p < 0.01 | BH: p = 0.20/FB: p < 0.01 |
| Bilateral lung | ||||||
| Mean (Gy) | 0.8 (0.4) | 2.6 (0.9) | 0.9 (0.3) | 2.9 (1.1) | IMPT: p = 0.10/IMRT: p < 0.02 | p < 0.01 |
| D max (Gy) | 14.6 (8.0) | 33.4 (5.7) | 18.0 (6.9) | 35.5 (5.0) | p < 0.05 | p < 0.01 |
| V5 Gy (%) | 3.6 (1.9) | 10.1 (3.1) | 4.0 (1.2) | 10.1 (3.3) | IMPT: p = 0.08/IMRT: p = 0.90 | p < 0.01 |
| V20 Gy (%) | 1.3 (0.8) | 5.1 (2.2) | 1.5 (0.7) | 5.7 (2.6) | IMPT: p = 0.06/IMRT: p = 0.03 | p < 0.01 |
| Lung left | ||||||
| Mean (Gy) | 1.5 (0.6) | 5.4 (1.8) | 1.6 (0.6) | 6.1 (2.3) | IMPT: p = 0.20/IMRT: p < 0.01 | p < 0.01 |
| D max (Gy) | 23.6 (8.2) | 37.1 (2.8) | 27.0 (7.0) | 38.7 (2.3) | p < 0.04 | p < 0.01 |
| V5 Gy (%) | 7.1 (2.7) | 21.4 (6.6) | 7.7 (2.7) | 21.9 (7.1) | IMPT: p = 0.17/IMRT: p = 0.59 | p < 0.01 |
| V20 Gy (%) | 2.5 (1.4) | 10.9 (4.7) | 2.8 (1.4) | 12.4 (5.7) | IMPT: p = 0.04/IMRT: p = 0.02 | p < 0.01 |
| PTVtrim | ||||||
| V95 % (%) | 99.6 (0.32) | 97.9 (0.15) | 99.7 (0.19) | 97.9 (0.18) | IMPT: p = 0.09/IMRT: p = 0.70 | p < 0.01 |
| V107 % (%) | 0 | 0.4 (1.0) | 0 | 0.2 (0.4) | IMPT: p = 1.00/IMRT: p = 0.47 | p < 0.02 |
Non-significant data is presented in bold
BH breath-hold, FB free-breathing, IMPT intensity modulated proton therapy, IMRT intensity modulated radiotherapy, V5, V10, V15, V20, V30, and V40 Gy volume receiving ≥5, 10, 15, 20, 30, and 40 Gy, respectively, D max dose encompassing 2 % of the volume. V95 % and V107 % volume receiving ≥95 and 107 % of the prescribed dose, respectively