Figure 1. Epithelial-to-mesenchymal transition (EMT) pathways deregulated in cancer and the downstream effects.

Citrobacter rodentium (CR) binding to the luminal surface of the large intestine in a susceptible host can influence the epigenetic signaling within the stem (green) and/or progenitor (blue) cells to promote inflammation and EMT. The diagram demonstrates a variety of effector pathways for EMT as well as the downstream consequences related to either local invasion or distant metastasis. Dotted lines and question marks represent the current focus in our laboratory.