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. 2014 Jul 13;5(16):6936–6946. doi: 10.18632/oncotarget.2206

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Copyright: © 2014 Liang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Immunoblot analysis shows that downregulation of Akt by DN-Akt results in an increased in N-cadherin and decreased in vimentin protein expression in AML. In addition, downregulation of S6K by DN-S6K results in decreased in vimentin and increased in N-cadherin protein expression in AML cells. Rictor and Raptor regulates N-cadherin and vimentin (C) Immunoblot analysis shows that downregulation of rictor by siRNA directed against rictor results in decreased in vimentin expression and increased in N-cadherin protein expression in AML cells. In addition, downregulation of raptor by siRNA directed against raptor (D) results in decreased in vimentin expression and increased in N-cadherin protein expression in AML cells. GAPDH was used as a loading control.