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. 2014 Sep 30;5(5):e01530-14. doi: 10.1128/mBio.01530-14

FIG 4 .

FIG 4 

Expression of genes encoding proteins involved in hepatic lipid metabolism in mice harboring a simplified human intestinal microbiota (SIHUMI), SIHUMI without C. ramosum (SIHUMIw/oCra) or C. ramosum only (Cra) after 4 weeks of high-fat diet feeding. (A) Gene coding for fat transport protein fatty acid translocase (Cd36). (B and C) Genes coding for fatty acid synthesis proteins acetyl-CoA carboxylase 1 (Acaca) and fatty acid synthase (Fasn). (D and E) Genes coding for triglyceride synthesis proteins glycerol-3-phosphate acyltransferase 1 (Gpat1) and diacylglycerol acyltransferase 2 (Dgat2). (F) Gene coding for cholesterol synthesis protein HMG-CoA reductase (Hmgcr). (G and H) Genes coding for fatty acid catabolism proteins peroxisome proliferator-activated receptor alpha (Ppara) and carnitine palmitoyltransferase 1a (Cpt1a). Mean values ± SEM are shown. n = 8 to 9 mice per group. *, P < 0.05, and **, P < 0.01, for obese SIHUMI or Cra mice versus less obese SIHUMIw/oCra mice (reference). n.s., not significant.