FIG 1 .

BRIG diagram showing an overview of the genomic relationship between strain VCS1703A and the 103 sequenced strains of D. nodosus. Black arcs and labels at the edge of the circle indicate the eight nominally variable regions. Each sequenced isolate is represented as a colored ring, with a solid color representing greater than 95% sequence identity and a white region showing areas with less than 50% sequence identity to VCS1703A. A gradient of color is used to represent sequences in the range of 50 to 95% identity. The colors indicate the country of origin and the protease genotype. The major color groups are Denmark (gray), Sweden (light blue and dark blue), Norway (pink and red), and Australia (yellow and green). Gray, dark blue, red, and green indicate isolates with a virulent AprV2 (Y92) protease. Light blue, pink, and yellow indicate isolates with a benign AprB2 (R92) protease. The four innermost rings are the isolates from the United Kingdom, Nepal, Bhutan, and India, respectively.